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Protein kinase inhibitor H-7 dihydrochloride
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Catalog No. T22831Cas No. 108930-17-2
Alias H-7 dihydrochloride
Protein kinase inhibitor H-7 dihydrochloride(H-7 dihydrochloride) is a potent protein kinase C (PKC) inhibitor. Protein kinase inhibitor H-7 dihydrochloride (100 μM) significantly inhibits TPA (skin tumor promoter, 12-O-tetradecanoylphorbol-13-acetate) and phospholipase C-induced ODC (ornithine decarboxylase) inhibited PMA-induced promiscuity cell lysis activity.
Protein kinase inhibitor H-7 dihydrochloride
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Purity: 99.81%
Catalog No. T22831Alias H-7 dihydrochlorideCas No. 108930-17-2
Protein kinase inhibitor H-7 dihydrochloride(H-7 dihydrochloride) is a potent protein kinase C (PKC) inhibitor. Protein kinase inhibitor H-7 dihydrochloride (100 μM) significantly inhibits TPA (skin tumor promoter, 12-O-tetradecanoylphorbol-13-acetate) and phospholipase C-induced ODC (ornithine decarboxylase) inhibited PMA-induced promiscuity cell lysis activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $32 | - | In Stock | |
| 25 mg | $68 | - | In Stock | |
| 50 mg | $111 | - | In Stock | |
| 100 mg | $177 | - | In Stock | |
| 200 mg | $258 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.81%
Appearance:Solid
Color:Yellow
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Product Introduction
Protein kinase inhibitor H-7 dihydrochloride AI Summary
Protein kinase inhibitor H-7 dihydrochloride exhibits a range of bioactivities, including the inhibition of protein kinase C (PKC) with an IC50 of 6000.0 nM and cAMP-dependent protein kinase (PKA) with an IC50 of 3500.0 nM. It displaces ATP from PKC with a Ki of 6000.0 nM and from PKA with a Ki of 3000.0 nM. Additionally, it demonstrates antiplasmodial activity against Plasmodium falciparum strains 7G8, GB4, and W2 with IC50 values between 6309.57 nM and 12589.25 nM. Further functionalities include modulating Lamin A splicing, inducing the erasure of genomic imprints, enhancing SMN2 splice variant expression, and inhibiting Aldehyde Dehydrogenase 1 (ALDH1A1). Protein kinase inhibitor H-7 dihydrochloride also modulates Human Peripheral Myelin Protein 22 (PMP22) expression, induces DNA re-replication in MCF 10A cells, inhibits MPP8 chromodomain interactions with methylated histone tails, acts as an hERG channel inhibitor, and inhibits the binding or entry of Marburg Virus into cells..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Protein kinase inhibitor H-7 dihydrochloride(H-7 dihydrochloride) is a potent protein kinase C (PKC) inhibitor. Protein kinase inhibitor H-7 dihydrochloride (100 μM) significantly inhibits TPA (skin tumor promoter, 12-O-tetradecanoylphorbol-13-acetate) and phospholipase C-induced ODC (ornithine decarboxylase) inhibited PMA-induced promiscuity cell lysis activity. |
| Synonyms | H-7 dihydrochloride |
| Molecular Weight | 364.29 |
| Formula | C14H19Cl2N3O2S |
| Cas No. | 108930-17-2 |
| Smiles | Cl.Cl.CC1CNCCN1S(=O)(=O)c1cccc2cnccc12 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (150.98 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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